Imininingwane yomkhiqizo

ITroxerutin iyisixazululo esisodwa se-semi-synthetic flavonoid esihlelwe njenge-hydroxyethylrutoside, ibonakala njengothuli olukhanyayo oluya kokubomvu. Le mveliso ye-bioactive inefomula yemolekyuli ye-C33H42O19 kanye nesisindo semolekyuli esingu-742.68 g/mol, iqukethe i-quercetin backbone eguqulwe nge-rutinoside kanye ne-hydroxyethyl groups. Le mveliso ibonisa ukujula okuphakathi emanzini okukhula ngokushisa kanye ne-pH, ngenkathi ibonisa ukujula okuhle ezixubeni ezipholile ezinjenge-ethanol ne-dimethyl sulfoxide. ITroxerutin ibonisa ukuzinza ngaphansi kwezimo zokugcina ezijwayelekile uma ivikelwe ekukhanyeni nasekukhanyeni, ngokuzinza okuhle okubonwa ezishiseni ezingaphansi kuka-25°C. Ukuhlonza kwe-analytical ngokuvamile kuhlanganisa i-HPLC enokutholwa kwe-UV ku-257 nm kanye no-350 nm, kubonisa ama-absorption peaks akhethekile emikhiqizweni ye-flavonoid. Imathiriyeli ye-pharmaceutical-grade iqukethe ≥95% ubuqotho, ngokulawulwa okuqinile kwezinto ezihlobene kuhlanganisa i-quercetin (≤1.0%) kanye ne-rutin (≤2.0%). Isakhiwo se-crystalline sinesigaba esiningi se-phenolic hydroxyl groups esisiza kokubili ezimpahleni zayo zokulwa nezinto ezilimazayo kanye nephrofayili yokujula ye-pH. I-log P value yemkhiqizo ingu-1.5 ibonisa ukujula okuphakathi kwe-lipophilicity, kuthonya ukuvuleka kwayo emembraneni.

Ukusetshenziswa & Umsebenzi

I-Troxerutin isebenza ikakhulu njenge-venoactive kanye ne-microcirculation-improving agent ngezindlela eziningi ezihlanganisa ukucwenga ama-radical mahhala, ukuvinjwa kwezithako ezibangela ukuvuvukala, nokwehliswa kokungena kwe-capillary. Le misebenzi eminingi iyenza ibe nezinzuzo ezibalulekile ekwelapheni i-chronic venous insufficiency, ama-hemorrhoids, kanye ne-varicose veins kumaphilisi ajwayelekile angu-300-600 mg kathathu ngosuku. Le ngxube ibonisa ukusebenza kahle okukhethekile ku-diabetic microangiopathy ngokuvikela ama-endothelial cells ekulimazweni okubangelwa yi-hyperglycemia ngezakhiwo zayo zokulwa ne-oxidant kanye nezokulwa nokuvuvukala. E-opthalmology, amafomula e-troxerutin asetshenziswa ekwelapheni ukuvinjwa kwe-retinal vein kanye ne-diabetic retinopathy ngokuthuthukisa ukuhamba kwegazi kwi-retina nokwehlisa ukuvuza kwezitho zomzimba. Ikhono le ngxube lokuzinza kwe-membrane ye-lysosomal nokuvinjelwa komsebenzi we-hyaluronidase kunomthelela ezithombeni zayo zokulwa ne-edematous ekukhuleni kokuhlinzwa nasekukhuleni okukhulayo. Izicelo ezengeziwe zifaka ukuvikela kwe-neuro ngokumelene ne-ischemic stroke kanye nokuphazamiseka kokucabanga ngokusebenzisa ikhono layo lokungena emgudwini wegazi-ubuchopho kanye nemiphumela yokuvikela ye-mitochondrial. I-Troxerutin inenhlonipho yokuphepha, eneziphumo ezithile ezibikwe ezincane kumaphilisi okwelapha, iholele ekusetshenzisweni kwayo kabanzi ekuphathweni kwezempilo kwezakhiwo zesikhathi eside. Ucwaningo oluphakanyisiwe lukhombisa izicelo ezingaba khona ekuvimbeleni ubungozi bezitho zomzimba obubangelwa yi-chemotherapy kanye njengomphakathi ekuphathweni kwe-metabolic syndrome ngokusebenzisa imiphumela yayo yokushintsha ama-lipid kanye nokwenza i-insulin ibe nomthelela.