Imininingwane yomkhiqizo

I-Troxerutin iyisithako se-flavonoid esiyinsalela-synthetic esihlelwe njenge-hydroxyethylrutoside, ibonakala njengepowder ye-crystalline ephuzi ukuya kokukhanya. Le ngxenye ye-bioactive inefomula yemolekyuli ye-C33H42O19 kanye nesisindo semolekyuli esingu-742.68 g/mol, iqukethe i-quercetin backbone eguqulwe nge-rutinoside kanye nama-hydroxyethyl groups. Le ngxenye ibonisa ukujula okuphakathi kokuxubha emanzini okukhula ngokushisa kanye ne-pH, ngenkathi ibonisa ukujula okuhle ezixubeni ze-organic ezipholile ezifana ne-ethanol kanye ne-dimethyl sulfoxide. I-Troxerutin ibonisa ukuzinza ngaphansi kwezimo zokugcina ezijwayelekile uma ivikelwe ekukhanyeni nasekumanzi, ngokuzinza okuhle okubonwa ezishisweni ezingaphansi kuka-25°C. Ukuhlonza kwe-analytical kuvame ukufaka i-HPLC enokutholwa kwe-UV ku-257 nm kanye no-350 nm, kubonisa ama-absorption peaks ahlukile ezithakweni ze-flavonoid. Impahla ye-pharmaceutical-grade iqukethe ≥95% ubuqotho, ngokulawula okuqinile kwezinto ezihlobene kuhlanganisa i-quercetin (≤1.0%) kanye ne-rutin (≤2.0%). Isakhiwo se-crystalline sinesigaba esiningi se-phenolic hydroxyl groups esisiza kokubili ezimpahleni zayo zokulwa nezinto ezilimazayo kanye nephrofayili yokuxubha ehlobene ne-pH. Inani le-log P le ngxenye elingama-1.5 libonisa i-lipophilicity ephakathi, ethonya ukuvuleka kwayo emembraneni.

Ukusetshenziswa & Umsebenzi

I-Troxerutin isebenza ikakhulukazi njenge-venoactive kanye nesithako sokuthuthukisa umjikelezo omncane ngezindlela eziningi ezihlanganisa ukuhamba kwamahhala kwe-radical, ukuvinjwa kwezithako ezibangela ukuvuvukala, nokwehliswa kokungena kwe-capillary. Le msebenzi ehlukahlukene iyenza ibe nentshisekelo kwezokwelapha ekwelapheni ukungasebenzi kahle kwemithambo ye-venous, ama-hemorrhoids, kanye nemithambo ye-varicose kumaphilisi ajwayelekile angama-300-600 mg kathathu ngosuku. Le ngxube ibonisa ukusebenza kahle ikakhulukazi ku-diabetic microangiopathy ngokuvikela amaseli e-endothelial emonakalweni okubangelwa yi-hyperglycemia ngezakhiwo zayo zokulwa ne-oxidant kanye nezokulwa nokuvuvukala. E-ophthalmology, amafomula e-troxerutin asetshenziswa ekwelapheni ukuvinjwa kwemithambo ye-retinal kanye ne-diabetic retinopathy ngokuthuthukisa ukuhamba kwegazi kwi-retina nokwehlisa ukuvuza kwemithambo. Ikhono le ngxube lokuzinzisa imikhawulo ye-lysosomal nokuvinjelwa kokusebenza kwe-hyaluronidase kunika umphumela wayo wokulwa ne-edematous ekukhuleni okwenziwe ngemva kokuhlinzwa nasekukhuleni okwenziwe ngengozi. Izicelo ezengeziwe zifaka ukuvikela kwe-neuro ngokumelene ne-ischemic stroke kanye nokuphazamiseka kokucabanga ngekhono layo lokungena emgudwini wegazi-ubuchopho kanye nemiphumela yokuvikela ye-mitochondrial. Iphrofayili yokuphepha ye-troxerutin, enezinhlungu ezithile ezibikiwe kumaphilisi okwelapha, iholele ekusetshenzisweni kwayo kabanzi ekuphathweni kwezempilo kwemithambo isikhathi eside. Ucwaningo olukhulayo luphakamisa izicelo ezingaba khona ekuvikelweni kokulimala kwemithambo okubangelwa yi-chemotherapy kanye njengokwesekela ekuphathweni kwe-metabolic syndrome ngeziphumo zayo zokushintsha ama-lipid kanye nokwenza kube lula i-insulin. Imiphumela ye-synergistic ye ngxube nezinye ama-flavonoids ithuthukisa inani layo lokwelapha ezinkingeni ezinzima zemithambo.