Urolithin A iyinhlanganisela yemvelo, i-metabolite ekhiqizwa amagciwane esiswini ahlukanisa izakhi ze-polyphenolic, ezifana ne-phytochromes, ezitholakala emathanjeni e-oak nasezithelo. Iyi-Compound enomthelela onokwenzeka wezempilo.
Urolithin A inezinhloso ezithile zokuphila, kuhlanganisa ne-antioxidant, i-anti-inflammatory, i-anti-cancer kanye ne-anti-aging. Ingase ibonise imiphumela yayo ngezindlela eziningi, njengokukhuthaza i-bioelectricity ye-mitochondrial, ukulawula izinqubo ze-autophagic, ukuvinjwa kwezindlela zokuvuvukala, nokuthinta ukusakazwa kwezicubu.

HPLC

Urolithin A unamafunction amaningi angaba khona kanye nemisebenzi ye-biological. Nansi eminye yemisebenzi ebalulekile ye-Urolithin A:
1. Umphumela we-antioxidant: Urolithin A ungumphumela ophakeme we-antioxidant ongakwazi ukuhlinzeka ngempumelelo kumaradiyali mahala futhi unciphise umonakalo wokucindezela kwe-oxidative kumaseli. Lokhu kusiza ukuvikela amaseli emonakalweni wokucindezela futhi kusiza ukugcina impilo yamaseli.
2. Khuthaza i-bioelectricity ye-mitochondrial: Urolithin A ingakhuthaza ukukhiqizwa nokusebenza kwe-mitochondria, ikhuphule izinga lamandla kumaseli. Lokhu kubalulekile ukugcina ukusebenza okujwayelekile kwamaseli kanye nezinqubo zokushintsha.
3. Ukulawula inqubo ye-autophagy: Urolithin A ingakhuthaza inqubo ye-autophagy kumaseli. I-autophagy iyindlela yokukhipha udoti ngaphakathi kweseli kanye nokwehliswa kweprotein esiza ukugcina impilo yeseli futhi ibambezele ukuguga.
4. Umphumela we-anti-inflammatory: Urolithin A inezakhiwo ze-anti-inflammatory, ezingavimbela impendulo yokuvuvukala, zinciphise ukukhiqizwa kwezithako zokuvuvukala kanye nokuvulwa kwezindlela zokukhuluma ezivuvukalayo. Lokhu kunezinzuzo ezingenzeka ekuvimbeleni nasekwehliseni izifo ezihlobene nokuvuvukala.
5. Umphumela we-anti-tumor: Ezinye izifundo zithole ukuthi Urolithin A inemiphumela yokuvimba kumaseli athile omdlavuza, futhi ingavimba ukukhula nokusabalala kwamacala omdlavuza. Nokho, kudingeka ucwaningo oluningi ukuze kutholakale inani lwayo elingaba khona ekwelashweni komdlavuza.
6. Umphumela wokulwa nokuguga: Izifundo zikhombisile ukuthi i-Urolithin A ingakwazi ukulawula indlela yokuguga kumaseli, ibambezelele inqubo yokuguga futhi ikhuthaze ukuphila isikhathi eside kwamaseli. Lokhu kungase kube nokuxhumana nezici zayo zokulwa nezinto ezilimazayo kanye nolawulo lwe-autophagy.

1. Impilo ye-gut: Urolithin A ingase ibe nezinzuzo empilweni ye-gut. Ingagcina ubuqotho be-mucosa ye-intestine futhi ivimbele ukuvuvukala kwe-intestine nezifo ezihlobene ezifana nesimo sokuphazamiseka kwe-intestine ngokulawula ibhalansi ye-flora ye-intestine, ukukhuthaza i-autophagy, nokunciphisa ukuvuvukala.
2. Impilo ye-cardiovascular: Ezinye izifundo zikhombisa ukuthi Urolithin A ingaba nemiphumela emihle empilweni ye-cardiovascular. Ineziphumo ze-antioxidant nezokulwa nokuvuvukala, ezinganciphisa umonakalo wokucindezela kanye nokuvuvukala egazini, ngaleyo ndlela ivimbele ukuvela nokuthuthukiswa kwezifo ze-cardiovascular.
3. Impilo yemisipha: Urolithin A ingaba nomthelela omuhle empilweni yemisipha nasekusebenzeni kwezemidlalo. Ucwaningo lukhombisa ukuthi ingakhuphula i-bioelectricity ye-mitochondrial, ithuthukise ukuhlinzekwa kwe-oxygen kwemisipha, futhi ithuthukise ukumelana nokuzivocavoca kanye nemisebenzi yemisipha.
4. Impilo yezinso: Ucwaningo lokuqala lukhombisa ukuthi Urolithin A ingase ibe nomthelela othile empilweni yezinso. Ingavimbela ukuvela kwezifo ezihlobene nezinsini ezifana ne-osteoporosis ngokukhuthaza ukusebenza okujwayelekile kwezicubu zezinso nokwandisa ubukhulu bezinsini.
5. Ukuvikelwa kwe-neuro: Urolithin A ingase ibe nemiphumela yokuvikela i-neuro, isiza ukuvimbela ukuthuthukiswa kwezifo ezithinta i-neuro, ezifana nesifo sika-Alzheimer kanye nesifo sika-Parkinson. Imiphumela yayo yokulwa nezinto ezilimazayo, yokuvuvukala kanye nokulawula i-autophagy ingase ibe nendima enhle ekuvikeleni nasekulungiseni izicubu zezinzwa.